UP Health System – Portage has been serving Michigan's Western Upper Peninsula since 1896. It supports a multi-specialty medical community with over 40 physicians and more than a dozen allied health professionals. The main campus features a 36-bed hospital, accredited as a chest pain center by the Society of Cardiovascular Patient Care (SCPC). UP Health System – Portage was the first in the state to achieve Level III ACC (American College of Cardiology) verification as a trauma center.

Additional services include dedicated physician hospitalists, cardiopulmonary services, elective and emergency orthopedics, women’s health, general surgery, hematology and oncology, internal medicine, sports medicine and rehabilitation and sports medicine, x-ray and diagnostics (including MRI, mobile PET scan, 64-slice CT scanner, nuclear imaging, and 3D mammography), an advanced wound care center, a sleep lab, two Express Care walk-in clinics, a regional dialysis unit, pharmacy services, laboratory services, home care, and a 60-bed senior living community.